Hutchinson Gilford Progeria Syndrome (HGPS) is a rare genetic disorder. The disorder is
characterized by premature aging, generally leading to death. The purpose of this article is to
review Hutchinson Gilford Progeria Syndrome and its characteristics. There are many symptoms from various organs such dermatology characteristics, facial features, and musculoskeletal disorders. The syndrome is characterized by specific radiological and histological findings. The diagnosis is based on the identification of common clinical features and the detection of mutation of specific gene. There are some types of treatment may facilitate or delay some of the signs and symptoms.A multidisciplinary team should intervene in order to increase the quality of life and survival of Hutchinson-Gilford progeria syndrome.